Publications for Simone Tambaro

Article

1	Maccioni R, Travisan C, Badman J, Zerial S, Wagener A, Andrade-Talavera Y, Picciau F, Grassi C, Chen G, Lemoine L, Fisahn A, Jiang R, Fluhrer R, Mentrup T, Schröder B, Nilsson P, Tambaro S. Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease. Progress in neurobiology 2024 235: 102585- View record in PubMed®
2	Tambaro S, Mitra S, Gera R, Linderoth B, Wahlberg LU, Darreh-Shori T, Behbahani H, Nilsson P, Eriksdotter M. Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to AppNL-G-F knock-in Alzheimer mice. Alzheimer's research & therapy 2023 15:1 137- View record in PubMed®
3	Manchanda S, Galan-Acosta L, Abelein A, Tambaro S, Chen G, Nilsson P, Johansson J. Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer's disease pathology in mouse models. Molecular therapy : the journal of the American Society of Gene Therapy 2023 31:2 487-502 View record in PubMed®
4	Medina-Vera D, Zhao HJ, Bereczki E, Rosell-Valle C, Shimozawa M, Chen GF, de Fonseca FR, Nilsson P, Tambaro S. The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer's Disease in App^NL-G-F Knock-In Mice. BIOLOGY-BASEL 2023 12:6 View record in PubMed®
5	Medina-Vera D, Enache D, Tambaro S, Abuhashish E, Rosell-Valle C, Winblad B, Rodríguez de Fonseca F, Bereczki E, Nilsson P. Translational potential of synaptic alterations in Alzheimer's disease patients and amyloid precursor protein knock-in mice. Brain communications 2023 5:1 fcad001- View record in PubMed®
6	Pang KL, Jiang RC, Zhang W, Yang ZY, Li LL, Shimozawa M, Tambaro S, Mayer J, Zhang BG, Li M, Wang JS, Liu H, Yang AL, Chen X, Liu JZ, Winblad B, Han H, Jiang TZ, Wang WW, Nilsson P, Guo W, Lu B. An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. CELL RESEARCH 2022 32:2 157-175 View record in PubMed®
7	Jiang RC, Shimozawa M, Mayer J, Tambaro S, Kumar R, Abelein A, Winblad B, Bogdanovic N, Nilsson P. Autophagy Impairment in App Knock-in Alzheimer's Model Mice. FRONTIERS IN AGING NEUROSCIENCE 2022 14: 878303- View record in PubMed®
8	Arroyo-García LE, Isla AG, Andrade-Talavera Y, Balleza-Tapia H, Loera-Valencia R, Alvarez-Jimenez L, Pizzirusso G, Tambaro S, Nilsson P, Fisahn A. Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease. Molecular psychiatry 2021 26:10 5557-5567 View record in PubMed®
9	Chen GF, Andrade-Talavera Y, Tambaro S, Leppert A, Nilsson HE, Zhong XY, Landreh M, Nilsson P, Hebert H, Biverstal H, Fisahn A, Abelein A, Johansson J. Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro. COMMUNICATIONS BIOLOGY 2020 3:1 32- View record in PubMed®
10	Galan-Acosta L, Sierra C, Leppert A, Pouliopoulos AN, Kwon N, Noel RL, Tambaro S, Presto J, Nilsson P, Konofagou EE, Johansson J. Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons. MOLECULAR AND CELLULAR NEUROSCIENCE 2020 105: 103498- View record in PubMed®
11	Tambaro S, Galan-Acosta L, Leppert A, Chen G, Biverstål H, Presto J, Nilsson P, Johansson J. Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice. The Journal of biological chemistry 2019 294:8 2606-2615 View record in PubMed®
12	Dolfe L, Tambaro S, Tigro H, Del Campo M, Hoozemans JJM, Wiehager B, Graff C, Winblad B, Ankarcrona M, Kaldmäe M, Teunissen CE, Rönnbäck A, Johansson J, Presto J. The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques. Journal of Alzheimer's disease reports 2018 2:1 27-39 View record in PubMed®
13	Chen G, Abelein A, Nilsson HE, Leppert A, Andrade-Talavera Y, Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck PJB, Presto J, Hebert H, Fisahn A, Johansson J. Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state. Nature communications 2017 8:1 2081- View record in PubMed®
14	Orrù A, Casu MA, Tambaro S, Marchese G, Casu G, Ruiu S. Withania somnifera (L.) Dunal root extract alleviates formalin-induced nociception in mice: involvement of the opioidergic system. Behavioural pharmacology 2016 27:1 57-68 View record in PubMed®
15	Tambaro S, Casu MA, Mastinu A, Lazzari P. Evaluation of selective cannabinoid CB(1) and CB(2) receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis. European journal of pharmacology 2014 729: 67-74 View record in PubMed®
16	Godar SC, Bortolato M, Castelli MP, Casti A, Casu A, Chen K, Ennas MG, Tambaro S, Shih JC. The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake. Journal of psychiatric research 2014 56: 1-9 View record in PubMed®
17	Bortolato M, Godar SC, Tambaro S, Li FG, Devoto P, Coba MP, Chen K, Shih JC. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology 2013 75: 223-32 View record in PubMed®
18	Frau R, Pillolla G, Bini V, Tambaro S, Devoto P, Bortolato M. Inhibition of 5α-reductase attenuates behavioral effects of D₁-, but not D₂-like receptor agonists in C57BL/6 mice. PSYCHONEUROENDOCRINOLOGY 2013 38:4 542-51 View record in PubMed®
19	Tambaro S, Tomasi ML, Bortolato M. Long-term CB₁ receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids. Neuropharmacology 2013 70: 268-77 View record in PubMed®
20	Tambaro S, Reali R, Volonterio A, Zanda M, Olimpieri F, Pinna GA, Lazzari P. NESS002ie: a new fluorinated thiol endopeptidase inhibitor with antinociceptive activity in an animal model of persistent pain. Pharmacology, biochemistry, and behavior 2013 110: 137-44 View record in PubMed®
21	Manca I, Mastinu A, Olimpieri F, Falzoi M, Sani M, Ruiu S, Loriga G, Volonterio A, Tambaro S, Bottazzi ME, Zanda M, Pinna GA, Lazzari P. Novel pyrazole derivatives as neutral CB₁ antagonists with significant activity towards food intake. European journal of medicinal chemistry 2013 62: 256-69 View record in PubMed®
22	Lazzari P, Pau A, Tambaro S, Asproni B, Ruiu S, Pinna G, Mastinu A, Curzu MM, Reali R, Bottazzi ME, Pinna GA, Murineddu G. Synthesis and pharmacological evaluation of novel 4-alkyl-5-thien-2'-yl pyrazole carboxamides. Central nervous system agents in medicinal chemistry 2012 12:4 254-76 View record in PubMed®
23	Luongo L, Palazzo E, Tambaro S, Giordano C, Gatta L, Scafuro MA, Rossi FS, Lazzari P, Pani L, de Novellis V, Malcangio M, Maione S. 1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice. NEUROBIOLOGY OF DISEASE 2010 37:1 177-85 View record in PubMed®
24	Olimpieri F, Tambaro S, Fustero S, Lazzari P, Sanchez-Roselló M, Pani L, Volonterio A, Zanda M. Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors. Bioorganic & medicinal chemistry letters 2009 19:16 4715-9 View record in PubMed®
25	Casu MA, Pisu C, Sanna A, Tambaro S, Spada GP, Mongeau R, Pani L. Effect of Δ⁹-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum:: An immunohistochemical study. BRAIN RESEARCH 2005 1048:1-2 41-7 View record in PubMed®
26	Tambaro S, Ruiu S, Dessi C, Mongeau R, Marchese G, Pani L. Evaluation of tamsulosin and alfuzosin activity in the rat vas deferens: relevance to ejaculation delays. The Journal of pharmacology and experimental therapeutics 2005 312:2 710-7 View record in PubMed®
27	Tambaro S, Mongeau R, Dessi C, Pani L, Ruiu S. Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors. European journal of pharmacology 2005 525:1-3 150-3 View record in PubMed®
28	Marchese G, Bartholini F, Casu MA, Ruiu S, Casti P, Congeddu E, Tambaro S, Pani L. Haloperidol versus risperidone on rat "early onset" vacuous chewing. Behavioural brain research 2004 149:1 9-16 View record in PubMed®
29	Ruiu S, Pinna GA, Marchese G, Mussinu JM, Saba P, Tambaro S, Casti P, Vargiu R, Pani L. Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor. The Journal of pharmacology and experimental therapeutics 2003 306:1 363-70 View record in PubMed®
30	Castagnola M, Cabras T, Denotti G, Fadda MB, Gambarini G, Lupi A, Manca I, Onnis G, Piras V, Soro V, Tambaro S, Messana I. Circadian rhythms of histatin 1, histatin 3, histatin 5, statherin and uric acid in whole human saliva secretion. BIOLOGICAL RHYTHM RESEARCH 2002 33:2 213-222

Review

1	Vassal M, Martins F, Monteiro B, Tambaro S, Martinez-Murillo R, Rebelo S. Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research. Molecular neurobiology 2025 62:1 46-76 View record in PubMed®
2	Morcuende A, García-Gutiérrez MS, Tambaro S, Nieto E, Manzanares J, Femenia T. Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders. Frontiers in psychiatry 2022 13: 866052- View record in PubMed®
3	Abate G, Uberti D, Tambaro S. Potential and Limits of Cannabinoids in Alzheimer's Disease Therapy. BIOLOGY-BASEL 2021 10:6 View record in PubMed®
4	Martins F, Santos I, da Cruz E Silva OAB, Tambaro S, Rebelo S. The role of the integral type II transmembrane protein BRI2 in health and disease. Cellular and molecular life sciences : CMLS 2021 78:21-22 6807-6822 View record in PubMed®
5	Premoli M, Aria F, Bonini SA, Maccarinelli G, Gianoncelli A, Pina SD, Tambaro S, Memo M, Mastinu A. Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment. Life sciences 2019 224: 120-127 View record in PubMed®
6	Mastinu A, Premoli M, Ferrari-Toninelli G, Tambaro S, Maccarinelli G, Memo M, Bonini SA. Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation. Hormone molecular biology and clinical investigation 2018 36:2 View record in PubMed®
7	Bonini SA, Premoli M, Tambaro S, Kumar A, Maccarinelli G, Memo M, Mastinu A. Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. Journal of ethnopharmacology 2018 227: 300-315 View record in PubMed®
8	Tambaro S, Bortolato M. Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent patents on CNS drug discovery 2012 7:1 25-40 View record in PubMed®

Other

1	Tambaro S, Galán-Acosta L, Leppert A, Presto J, Johansson J. BRICHOS - an anti-amyloid chaperone: evaluation of blood-brain barrier permeability of Bri2 BRICHOS. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2017 24:sup1 7-8 View record in PubMed®
2	Fadda MB, Masana I, Sofn V, Tambaro S, Pirus V, Denotti G, Gamharmi G, Zuppi C, Patama M, Giardina B, Castagnola M, Lupi A. The concentration of defensin-1 in human saliva.. JOURNAL OF DENTAL RESEARCH 2002 81: B252-B252
3	Cassiano M, Lupi A, Giardina B, Patamia M, Cassiano L, Tambaro S, Cordaro M, Onnis G, Manca I, Gambarini G, Messana I. The detection in human saliva of small peptides deriving from histatin-1 and histatin-3.. JOURNAL OF DENTAL RESEARCH 2002 81: B252-B252