Publications for Lars Sävendahl

Article

1 Chen SC, Bryce J, Chen M, Charmandari E, Choi JH, Dou X, Gong C, Hamza R, Harvey J, Hoffman AR, Horikawa R, Johannson G, Jorge AAL, Miller BS, Roehrich S, Sävendahl L, Tseretopoulou X, Vitali D, Wajnrajch M, Ahmed SF. Development of a Minimum Dataset for the Monitoring of Recombinant Human Growth Hormone Therapy in Children with Growth Hormone Deficiency: A GloBE-Reg Initiative. Hormone research in paediatrics 2024 97:4 365-373

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Fulltext: https://doi.org/10.1159/000533763
2 Velentza L, Wickström M, Kogner P, Ohlsson C, Zaman F, Sävendahl L. Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in Ex Vivo Cultured Rat Bones. Journal of the Endocrine Society 2024 8:3 bvae009-
3 Soucek O, Cinek O, Velentza L, Semjonov V, Bezdicka M, Zaman F, Sävendahl L. Lithium rescues cultured rat metatarsals from dexamethasone-induced growth failure. Pediatric research 2024 96:4 952-963

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Fulltext: https://doi.org/10.1038/s41390-024-03192-6
4 Tidblad A, Bottai M, Smedby KE, Albertsson-Wikland K, Sävendahl L. Long-term risk of neoplastic events after childhood growth hormone treatment: a population-based cohort study in Sweden. Frontiers in endocrinology 2024 15: 1360139-

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Fulltext: https://doi.org/10.3389/fendo.2024.1360139
5 Aeppli TR, Benyi E, Wehtje H, Chrysis D, Sävendahl L. Safety and Efficacy of Bilateral Epiphysiodesis Surgery to Reduce Final Height in Extremely Tall Adolescents - A Follow-up Study. Hormone research in paediatrics 2024 :

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Fulltext: https://doi.org/10.1159/000538016
6 Chapke R, Mondkar S, Oza C, Khadilkar V, Aeppli TRJ, Sävendahl L, Kajale N, Ladkat D, Khadilkar A, Goel P. The automated Greulich and Pyle: a coming-of-age for segmental methods?. Frontiers in artificial intelligence 2024 7: 1326488-
7 Zhao Y, Mäkitie O, Laakso S, Fedosova V, Sävendahl L, Zaman F. A novel link between chronic inflammation and humanin regulation in children. Frontiers in endocrinology 2023 14: 1142310-

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Fulltext: https://doi.org/10.3389/fendo.2023.1142310
8 Backeljauw P, Blair JC, Ferran JM, Kelepouris N, Miller BS, Pietropoli A, Polak M, Sävendahl L, Verlinde F, Rohrer TR. Early GH Treatment Is Effective and Well Tolerated in Children With Turner Syndrome: NordiNet® IOS and Answer Program. The Journal of clinical endocrinology and metabolism 2023 108:10 2653-2665

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Fulltext: https://doi.org/10.1210/clinem/dgad159
9 Smew AI, Lundholm C, Gong T, Sävendahl L, Lichtenstein P, Brew BK, Almqvist C. Maternal depression or anxiety during pregnancy and offspring type 1 diabetes: a population-based family-design cohort study. BMJ open diabetes research & care 2023 11:2

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Fulltext: https://doi.org/10.1136/bmjdrc-2023-003303
10 Zhang ZP, Zaman F, Nava TS, Aeppli TRJ, Gutierrez-Farewik EM, Kulachenko A, Savendahl L. Micromechanical Loading Studies in Ex Vivo Cultured Embryonic Rat Bones Enabled by a Newly Developed Portable Loading Device. ANNALS OF BIOMEDICAL ENGINEERING 2023 51:10 2229-2236

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Fulltext: https://doi.org/10.1007/s10439-023-03258-2
11 Velentza L, Wickström M, Kogner P, Ohlsson C, Zaman F, Sävendahl L. Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth. Scientific reports 2023 13:1 8054-

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Fulltext: https://doi.org/10.1038/s41598-023-34965-4
12 Mistry JN, Silvennoinen S, Zaman F, Sävendahl L, Mariniello K, Hall C, Howard SR, Dunkel L, Sankilampi U, Guasti L. The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants. Frontiers in endocrinology 2023 14: 1105602-

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Fulltext: https://doi.org/10.3389/fendo.2023.1105602
13 Sävendahl L, Battelino T, Højby Rasmussen M, Brod M, Röhrich S, Saenger P, Horikawa R. Weekly Somapacitan in GH Deficiency: 4-Year Efficacy, Safety, and Treatment/Disease Burden Results From REAL 3. The Journal of clinical endocrinology and metabolism 2023 108:10 2569-2578

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Fulltext: https://doi.org/10.1210/clinem/dgad183
14 Savendahl L, Battelino T, Rasmussen MH, Brod M, Saenger P, Horikawa R. Effective GH Replacement With Once-weekly Somapacitan vs Daily GH in Children with GHD: 3-year Results From REAL 3. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2022 107:5 1357-1367

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Fulltext: https://doi.org/10.1210/clinem/dgab928
15 Ramesh S, Zaman F, Sävendahl L, Madhuri V. Radial shockwave treatment promotes chondrogenesis in human growth plate and longitudinal bone growth in rabbits. Bone 2022 154: 116186-

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Fulltext: https://doi.org/10.1016/j.bone.2021.116186
16 Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L, Touraine P, van Santen HM, Johannsson G. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement. European journal of endocrinology 2022 186:6 P35-P52

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Fulltext: https://doi.org/10.1530/EJE-21-1186
17 Zhao Y, Celvin B, Denis MC, Karagianni N, Aulin C, Zaman F, Sävendahl L. TNF overexpression and dexamethasone treatment impair chondrogenesis and bone growth in an additive manner. Scientific reports 2022 12:1 18189-

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Fulltext: https://doi.org/10.1038/s41598-022-22734-8
18 Tidblad A, Bottai M, Kieler H, Albertsson-Wikland K, Savendahl L. Association of Childhood Growth Hormone Treatment With Long-term Cardiovascular Morbidity. JAMA PEDIATRICS 2021 175:2 e205199-
19 Lennartsson O, Lodefalk M, Wehtje H, Stattin EL, Sävendahl L, Nilsson O. Case Report: Bilateral Epiphysiodesis Due to Extreme Tall Stature in a Girl With a De Novo DNMT3A Variant Associated With Tatton-Brown-Rahman Syndrome. Frontiers in endocrinology 2021 12: 752756-

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Fulltext: https://doi.org/10.3389/fendo.2021.752756
20 Rohrer TR, Abuzzahab J, Backeljauw P, Birkegard AC, Blair J, Dahlgren J, Juliusson PB, Ostrow V, Pietropoli A, Polak M, Romano A, Ross J, Savendahl L, Miller BS. Long-Term Effectiveness and Safety of Childhood Growth Hormone Treatment in Noonan Syndrome. HORMONE RESEARCH IN PAEDIATRICS 2021 93:6 380-395

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Fulltext: https://doi.org/10.1159/000512429
21 Sävendahl L, Polak M, Backeljauw P, Blair JC, Miller BS, Rohrer TR, Hokken-Koelega A, Pietropoli A, Kelepouris N, Ross J. Long-Term Safety of Growth Hormone Treatment in Childhood: Two Large Observational Studies: NordiNet IOS and ANSWER. The Journal of clinical endocrinology and metabolism 2021 106:6 1728-1741

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Fulltext: https://doi.org/10.1210/clinem/dgab080
22 Mouratidou N, Malmborg P, Sachs MC, Askling J, Ekbom A, Neovius M, Smedby KE, Sävendahl L, Ludvigsson JF, Olén O. Adult height in patients with childhood-onset inflammatory bowel disease: a nationwide population-based cohort study. Alimentary pharmacology & therapeutics 2020 51:8 789-800

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Fulltext: https://doi.org/10.1111/apt.15667
23 Smew AI, Lundholm C, Sävendahl L, Lichtenstein P, Almqvist C. Familial Coaggregation of Asthma and Type 1 Diabetes in Children. JAMA network open 2020 3:3 e200834-
24 Mårild K, Ohlsson C, Bygdell M, Martikainen J, Sävendahl L, Størdal K, Kindblom JM. Growth and Pubertal Timing in Boys With Adult-diagnosed Celiac Disease: A Population-based Longitudinal Cohort Study. Journal of pediatric gastroenterology and nutrition 2020 70:6 853-857
25 Celvin B, Zaman F, Aulin C, Sävendahl L. Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis. Clinical and experimental rheumatology 2020 38:1 129-135

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26 Sävendahl L, Cooke R, Tidblad A, Beckers D, Butler G, Cianfarani S, Clayton P, Coste J, Hokken-Koelega ACS, Kiess W, Kuehni CE, Albertsson-Wikland K, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Konrad D, Landier F, Pfaeffle R, Sommer G, Thomas M, Tollerfield S, Zandwijken GRJ, Carel JC, Swerdlow AJ. Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study. The lancet. Diabetes & endocrinology 2020 8:8 683-692
27 Sävendahl L, Battelino T, Brod M, Højby Rasmussen M, Horikawa R, Juul RV, Saenger P, REAL 3 study group. Once-Weekly Somapacitan vs Daily GH in Children With GH Deficiency: Results From a Randomized Phase 2 Trial. The Journal of clinical endocrinology and metabolism 2020 105:4

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Fulltext: https://doi.org/10.1210/clinem/dgz310
28 Ramesh S, Zaman F, Madhuri V, Sävendahl L. Radial Extracorporeal Shock Wave Treatment Promotes Bone Growth and Chondrogenesis in Cultured Fetal Rat Metatarsal Bones. Clinical orthopaedics and related research 2020 478:3 668-678
29 Ramesh S, Savendahl L, Madhuri V, Zaman F. Radial shock waves prevent growth retardation caused by the clinically used drug vismodegib in ex vivo cultured bones. SCIENTIFIC REPORTS 2020 10:1 13400-

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Fulltext: https://doi.org/10.1038/s41598-020-69904-0
30 Benyi E, Linder M, Adami J, Kieler H, Palme M, Sävendahl L. Adult height is associated with risk of cancer and mortality in 5.5 million Swedish women and men. Journal of epidemiology and community health 2019 73:8 730-736

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Fulltext: https://doi.org/10.1136/jech-2018-211040
31 Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sävendahl L, Chagin AS. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature 2019 567:7747 234-238

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Fulltext: https://doi.org/10.1038/s41586-019-0989-6
32 Hedman A, Breithaupt L, Hübel C, Thornton LM, Tillander A, Norring C, Birgegård A, Larsson H, Ludvigsson JF, Sävendahl L, Almqvist C, Bulik CM. Bidirectional relationship between eating disorders and autoimmune diseases. Journal of child psychology and psychiatry, and allied disciplines 2019 60:7 803-812

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Fulltext: https://doi.org/10.1111/jcpp.12958
33 Haffner D, Emma F, Eastwood DM, Duplan MB, Bacchetta J, Schnabel D, Wicart P, Bockenhauer D, Santos F, Levtchenko E, Harvengt P, Kirchhoff M, Di Rocco F, Chaussain C, Brandi ML, Savendahl L, Briot K, Kamenicky P, Rejnmark L, Linglart A. Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia. Nature reviews. Nephrology 2019 15:7 435-455

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Fulltext: https://doi.org/10.1038/s41581-019-0152-5
34 Iravani M, Lagerquist MK, Karimian E, Chagin AS, OhIsson C, Savendahl L. Effects of the selective GPER1 agonist G1 on bone growth. ENDOCRINE CONNECTIONS 2019 8:9 1302-1309

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Fulltext: https://doi.org/10.1530/EC-19-0274
35 Dahl S, Kristoffersen Wiberg M, Teär Fahnehjelm K, Sävendahl L, Wickström R. High prevalence of pituitary hormone deficiency in both unilateral and bilateral optic nerve hypoplasia. Acta paediatrica (Oslo, Norway : 1992) 2019 108:9 1677-1685

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Fulltext: https://doi.org/10.1111/apa.14751
36 Zaman F, Zhao Y, Celvin B, Mehta HH, Wan J, Chrysis D, Ohlsson C, Fadeel B, Cohen P, Sävendahl L. Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 33:4 4962-4974

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Fulltext: https://doi.org/10.1096/fj.201801741R
37 Swerdlow AJ, Cooke R, Beckers D, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Hokken-Koelega ACS, Khan AJ, Kiess W, Kuehni CE, Flück CE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Zandwijken GRJ. Risk of Meningioma in European Patients Treated With Growth Hormone in Childhood: Results From the SAGhE Cohort. The Journal of clinical endocrinology and metabolism 2019 104:3 658-664

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Fulltext: https://doi.org/10.1210/jc.2018-01133
38 Ohlsson C, Bygdell M, Celind J, Sonden A, Tidblad A, Savendahl L, Kindblom JM. Secular Trends in Pubertal Growth Acceleration in Swedish Boys Born From 1947 to 1996. JAMA PEDIATRICS 2019 173:9 860-865
39 Savendahl L, Polak M, Backeljauw P, Blair J, Miller BS, Rohrer TR, Pietropoli A, Ostrow V, Ross J. Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet® IOS and ANSWER Program. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2019 104:10 4730-4742

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Fulltext: https://doi.org/10.1210/jc.2019-00775
40 Newton PT, Xie M, Medvedeva EV, Sävendahl L, Chagin AS. Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered. Bone reports 2018 8: 64-71
41 Swerdlow AJ, Cooke R, Beckers D, Borgström B, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Hokken-Koelega ACS, Khan AJ, Kiess W, Kuehni CE, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Van Eycken L, Zandwijken GRJ. Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study. The Journal of clinical endocrinology and metabolism 2017 102:5 1661-1672

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Fulltext: https://doi.org/10.1210/jc.2016-2046
42 Iravani M, Lagerquist M, Ohlsson C, Sävendahl L. Regulation of bone growth via ligand-specific activation of estrogen receptor alpha. The Journal of endocrinology 2017 232:3 403-410

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Fulltext: https://doi.org/10.1530/JOE-16-0263
43 Battelino T, Rasmussen MH, De Schepper J, Zuckerman-Levin N, Gucev Z, Sävendahl L, NN8640-4042 Study Group. Somapacitan, a once-weekly reversible albumin-binding GH derivative, in children with GH deficiency: A randomized dose-escalation trial. Clinical endocrinology 2017 87:4 350-358

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Fulltext: https://doi.org/10.1111/cen.13409
44 Allen DB, Backeljauw P, Bidlingmaier M, Biller BM, Boguszewski M, Burman P, Butler G, Chihara K, Christiansen J, Cianfarani S, Clayton P, Clemmons D, Cohen P, Darendeliler F, Deal C, Dunger D, Erfurth EM, Fuqua JS, Grimberg A, Haymond M, Higham C, Ho K, Hoffman AR, Hokken-Koelega A, Johannsson G, Juul A, Kopchick J, Lee P, Pollak M, Radovick S, Robison L, Rosenfeld R, Ross RJ, Savendahl L, Saenger P, Sorensen HT, Stochholm K, Strasburger C, Swerdlow A, Thorner M. GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults. European journal of endocrinology 2016 174:2 P1-9

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Fulltext: https://doi.org/10.1530/EJE-15-0873
45 Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. The Journal of clinical endocrinology and metabolism 2016 101:2 394-415

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Fulltext: https://doi.org/10.1210/jc.2015-2175
46 Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. Hormone research in paediatrics 2016 85:2 83-106

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Fulltext: https://doi.org/10.1159/000443136
47 Sävendahl L, Pournara E, Pedersen BT, Blankenstein O. Is safety of childhood growth hormone therapy related to dose? Data from a large observational study. European journal of endocrinology 2016 174:5 681-91

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Fulltext: https://doi.org/10.1530/EJE-15-1017
48 Albertsson-Wikland K, Mårtensson A, Sävendahl L, Niklasson A, Bang P, Dahlgren J, Gustafsson J, Kriström B, Norgren S, Pehrsson NG, Odén A. Mortality Is Not Increased in Recombinant Human Growth Hormone-treated Patients When Adjusting for Birth Characteristics. The Journal of clinical endocrinology and metabolism 2016 101:5 2149-59

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Fulltext: https://doi.org/10.1210/jc.2015-3951
49 Hannema SE, Sävendahl L. The Evaluation and Management of Tall Stature. Hormone research in paediatrics 2016 85:5 347-52

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Fulltext: https://doi.org/10.1159/000443685
50 Swerdlow AJ, Cooke R, Albertsson-Wikland K, Borgström B, Butler G, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Kiess W, Hokken-Koelega AC, Kuehni CE, Landier F, Maes M, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tollerfield S, Zandwijken GR, Carel JC. Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone. Hormone research in paediatrics 2015 84:3 172-83

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Fulltext: https://doi.org/10.1159/000435856
51 Cedervall T, Lind PM, Sävendahl L. Expression of the aryl hydrocarbon receptor in growth plate cartilage and the impact of its local modulation on longitudinal bone growth. International journal of molecular sciences 2015 16:4 8059-69

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Fulltext: https://doi.org/10.3390/ijms16048059
52 Reynaert N, Ockeloen CW, Sävendahl L, Beckers D, Devriendt K, Kleefstra T, Carels CE, Grigelioniene G, Nordgren A, Francois I, de Zegher F, Casteels K. Short Stature in KBG Syndrome: First Responses to Growth Hormone Treatment. Hormone research in paediatrics 2015 83:5 361-4

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Fulltext: https://doi.org/10.1159/000380908
53 Hou M, Eriksson E, Svechnikov K, Jahnukainen K, Söder O, Meinhardt A, Sävendahl L. Bortezomib treatment causes long-term testicular dysfunction in young male mice. Molecular cancer 2014 13: 155-

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Fulltext: https://doi.org/10.1186/1476-4598-13-155
54 Sundström K, Cedervall T, Ohlsson C, Camacho-Hübner C, Sävendahl L. Combined treatment with GH and IGF-I: additive effect on cortical bone mass but not on linear bone growth in female rats. Endocrinology 2014 155:12 4798-807

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Fulltext: https://doi.org/10.1210/en.2014-1160
55 Liu F, Hendriks AE, Ralf A, Boot AM, Benyi E, Sävendahl L, Oostra BA, van Duijn C, Hofman A, Rivadeneira F, Uitterlinden AG, Drop SL, Kayser M. Common DNA variants predict tall stature in Europeans. Human genetics 2014 133:5 587-97

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Fulltext: https://doi.org/10.1007/s00439-013-1394-0
56 Zaman F, Chrysis D, Huntjens K, Chagin A, Takigawa M, Fadeel B, Sävendahl L. Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid. Toxicology letters 2014 224:2 196-200
57 Dasgupta D, Wee MJ, Reyes M, Li Y, Simm PJ, Sharma A, Schlingmann KP, Janner M, Biggin A, Lazier J, Gessner M, Chrysis D, Tuchman S, Baluarte HJ, Levine MA, Tiosano D, Insogna K, Hanley DA, Carpenter TO, Ichikawa S, Hoppe B, Konrad M, Sävendahl L, Munns CF, Lee H, Jüppner H, Bergwitz C. Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis. Journal of the American Society of Nephrology : JASN 2014 25:10 2366-75

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Fulltext: https://doi.org/10.1681/ASN.2013101085
58 Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nature medicine 2014 20:11 1279-88

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Fulltext: https://doi.org/10.1038/nm.3654
59 Eriksson E, Wickström M, Perup LS, Johnsen JI, Eksborg S, Kogner P, Sävendahl L. Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment. Journal of the National Cancer Institute 2014 106:3 djt459-

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Fulltext: https://doi.org/10.1093/jnci/djt459
60 Benyi E, Kieler H, Linder M, Ritzén M, Carlstedt-Duke J, Tuvemo T, Westphal O, Sävendahl L. Risks of malignant and non-malignant tumours in tall women treated with high-dose oestrogen during adolescence. Hormone research in paediatrics 2014 82:2 89-96

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Fulltext: https://doi.org/10.1159/000360137
61 Wang L, Benedito R, Bixel MG, Zeuschner D, Stehling M, Sävendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH. Identification of a clonally expanding haematopoietic compartment in bone marrow. The EMBO journal 2013 32:2 219-30

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Fulltext: https://doi.org/10.1038/emboj.2012.308
62 Karimian E, Tamm C, Chagin AS, Samuelsson K, Kjartansdóttir KR, Ohlsson C, Sävendahl L. Resveratrol treatment delays growth plate fusion and improves bone growth in female rabbits. PloS one 2013 8:6 e67859-
63 Höybye C, Sävendahl L, Christesen HT, Lee P, Pedersen BT, Schlumpf M, Germak J, Ross J. The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Norditropin®). Clinical epidemiology 2013 5: 119-27
64 Bergström I, Blanck A, Sävendahl L. Vitamin D levels in children born to vitamin D-deficient mothers. Hormone research in paediatrics 2013 80:1 6-10

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65 Zaman F, Chrysis D, Huntjens K, Fadeel B, Savendahl L. Ablation of the Pro-Apoptotic Protein Bax Protects Mice from Glucocorticoid-Induced Bone Growth Impairment. PLOS ONE 2012 7:3 e33168-
66 Eriksson E, Zaman F, Chrysis D, Wehtje H, Heino TJ, Sävendahl L. Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice. PloS one 2012 7:11 e50523-
67 Lee PA, Sävendahl L, Oliver I, Tauber M, Blankenstein O, Ross J, Snajderova M, Rakov V, Pedersen BT, Christesen HT. Comparison of response to 2-years' growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observational studies. International journal of pediatric endocrinology 2012 2012:1 22-
68 Savendahl L, Blankenstein O, Oliver I, Christesen HT, Lee P, Pedersen BT, Rakov V, Ross J. Gender Influences Short-Term Growth Hormone Treatment Response in Children. HORMONE RESEARCH IN PAEDIATRICS 2012 77:3 188-94

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Fulltext: https://doi.org/10.1159/000337570
69 Savendahl L, Maes M, Albertsson-Wikland K, Borgstrom B, Carel JC, Henrard S, Speybroeck N, Thomas M, Zandwijken G, Hokken-Koelega A. Long-Term Mortality and Causes of Death in Isolated GHD, ISS, and SGA Patients Treated with Recombinant Growth Hormone during Childhood in Belgium, The Netherlands, and Sweden: Preliminary Report of 3 Countries Participating in the EU SAGhE Study. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2012 97:2 E213-7

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Fulltext: https://doi.org/10.1210/jc.2011-2882
70 Fernandez-Vojvodich P, Palmblad K, Karimian E, Andersson U, Savendahl L. Pro-Inflammatory Cytokines Produced by Growth Plate Chondrocytes May Act Locally to Modulate Longitudinal Bone Growth. HORMONE RESEARCH IN PAEDIATRICS 2012 77:3 180-7

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Fulltext: https://doi.org/10.1159/000337569
71 Sävendahl L. The effect of acute and chronic stress on growth. Science signaling 2012 5:247 pt9-

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Fulltext: https://doi.org/10.1126/scisignal.2003484
72 Borjesson AE, Windahl SH, Karimian E, Eriksson EE, Lagerquist MK, Engdahl C, Antal MC, Krust A, Chambon P, Savendahl L, Ohlsson C. The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2012 302:11 E1381-9

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Fulltext: https://doi.org/10.1152/ajpendo.00646.2011
73 Karimian E, Chagin AS, Sävendahl L. Genetic regulation of the growth plate. Frontiers in endocrinology 2011 2: 113-
74 Chrysis D, Chagin AS, Savendahl L. Insulin-like growth factor-1 restores dexamethasone-induced heart growth arrest in rats: the role of the ubiquitin pathway. HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM 2011 10:1 46-56

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Fulltext: https://doi.org/10.14310/horm.2002.1292
75 Heino TJ, Astrom E, Laurencikas E, Savendahl L, Soderhall S. Intravenous Pamidronate Treatment Improves Growth in Prepubertal Osteogenesis Imperfecta Patients. HORMONE RESEARCH IN PAEDIATRICS 2011 75:5 354-61

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Fulltext: https://doi.org/10.1159/000323370
76 Fernandez-Vojvodich P, Karimian E, Savendahl L. The Biologics Anakinra and Etanercept Prevent Cytokine-Induced Growth Retardation in Cultured Fetal Rat Metatarsal Bones. HORMONE RESEARCH IN PAEDIATRICS 2011 76:4 278-85

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Fulltext: https://doi.org/10.1159/000330726
77 Chagin AS, Karimian E, Sundstrom K, Eriksson E, Savendahl L. Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones. JOURNAL OF ENDOCRINOLOGY 2010 204:1 21-9

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Fulltext: https://doi.org/10.1677/JOE-09-0307
78 Benyi E, Berner M, Bjernekull I, Boman A, Chrysis D, Nilsson O, Waehre A, Wehtje H, Sävendahl L. Efficacy and Safety of Percutaneous Epiphysiodesis Operation around the Knee to Reduce Adult Height in Extremely Tall Adolescent Girls and Boys. International journal of pediatric endocrinology 2010 2010: 740629-
79 Emons J, Chagin AS, Malmlof T, Lekman M, Tivesten A, Ohlsson C, Wit JM, Karperien M, Savendahl L. Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development. JOURNAL OF ENDOCRINOLOGY 2010 205:1 61-8

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Fulltext: https://doi.org/10.1677/JOE-09-0337
80 Lindahl E, Nyman U, Zaman F, Palmberg C, Cascante A, Shafqat J, Takigawa M, Savendahl L, Jorvall H, Joseph B. Proinsulin C-peptide Regulates Ribosomal RNA Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 2010 285:5 3462-9

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Fulltext: https://doi.org/10.1074/jbc.M109.053587
81 Borjesson AE, Lagerquist MK, Liu C, Shao RJ, Windahl SH, Karlsson C, Sjogren K, Moverare-Skrtic S, Antal MC, Krust A, Mohan S, Chambon P, Savendahl L, Ohlsson C. The Role of Estrogen Receptor α in Growth Plate Cartilage for Longitudinal Bone Growth. JOURNAL OF BONE AND MINERAL RESEARCH 2010 25:12 2690-700

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Fulltext: https://doi.org/10.1002/jbmr.156
82 Thodberg HH, Savendahl L. Validation and Reference Values of Automated Bone Age Determination for Four Ethnicities. ACADEMIC RADIOLOGY 2010 17:11 1425-32

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Fulltext: https://doi.org/10.1016/j.acra.2010.06.007
83 Chagin AS, Vannesjo J, Savendahl L. Androgen Receptor Modulation Does Not Affect Longitudinal Growth of Cultured Fetal Rat Metatarsal Bones. HORMONE RESEARCH 2009 71:4 219-27

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Fulltext: https://doi.org/10.1159/000201111
84 Emons J, Chagin AS, Hultenby K, Zhivotovsky B, Wit JM, Karperien M, Savendahl L. Epiphyseal Fusion in the Human Growth Plate Does not Involve Classical Apoptosis. PEDIATRIC RESEARCH 2009 66:6 654-9
85 Chagin AS, Savendahl L. Genes of Importance in the Hormonal Regulation of Growth Plate Cartilage. HORMONE RESEARCH 2009 71: 41-7

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Fulltext: https://doi.org/10.1159/000192435
86 Ahmed SF, Savendahl L. Promoting Growth in Chronic Inflammatory Disease: Lessons from Studies of the Growth Plate. HORMONE RESEARCH 2009 72: 42-7

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Fulltext: https://doi.org/10.1159/000229763
87 Windahl SH, Andersson N, Chagin AS, Martensson UEA, Carlsten H, Olde B, Swanson C, Moverare-Skrtic S, Savendahl L, Lagerquist MK, Leeb-Lundberg LMF, Ohlsson C. The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2009 296:3 E490-6

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Fulltext: https://doi.org/10.1152/ajpendo.90691.2008
88 Heino TJ, Chagin AS, Takigawa M, Savendahl L. Effects of alendronate and pamidronate on cultured rat metatarsal bones:: Failure to prevent dexamethasone-induced growth retardation. BONE 2008 42:4 702-9

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Fulltext: https://doi.org/10.1016/j.bone.2008.01.001
89 Rafael E, Tibell A, Rydén M, Lundgren T, Sävendahl L, Borgström B, Arnelo U, Isaksson B, Nilsson B, Korsgren O, Permert J. Intramuscular autotransplantation of pancreatic islets in a 7-year-old child: a 2-year follow-up. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008 8:2 458-62
90 Karimian E, Chagin AS, Gjerde J, Heino T, Lien EA, Ohllsson C, Savendahl L. Tamoxifen impairs both longitudinal and cortical bone growth in young male rats. JOURNAL OF BONE AND MINERAL RESEARCH 2008 23:8 1267-77

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Fulltext: https://doi.org/10.1359/jbmr.080319
91 Miclea RL, Phillip M, Sävendahl L, Wit JM. The 7th ESPE Growth Plate Working Group symposium--EUROGROP, June 27th 2007, Helsinki, Finland. Journal of pediatric endocrinology & metabolism : JPEM 2008 21:3 287-94
92 Heino TJ, Chagin AS, Savendahl L. The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone. JOURNAL OF ENDOCRINOLOGY 2008 197:2 R1-6

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Fulltext: https://doi.org/10.1677/JOE-07-0629
93 Vojvodich PF, Hansen JB, Andersson U, Savendahl L, Hagelberg S. Etanercept treatment improves longitudinal growth in prepubertal children with juvenile idiopathic arthritis. JOURNAL OF RHEUMATOLOGY 2007 34:12 2481-5

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94 Chagin AS, Savendahl L. GPR30 estrogen receptor expression in the growth plate declines as puberty progresses. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2007 92:12 4873-7

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Fulltext: https://doi.org/10.1210/jc.2007-0814
95 Zaman F, Menendez-Benito V, Eriksson E, Chagin AS, Takigawa M, Fadeel B, Dantuma NP, Chrysis D, Saevendahl L. Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice. CANCER RESEARCH 2007 67:20 10078-86
96 Chagin AS, Karimian E, Zaman F, Takigawa M, Chrysis D, Savendahl L. Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones. BONE 2007 40:5 1415-24

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Fulltext: https://doi.org/10.1016/j.bone.2006.12.066
97 Chagin AS, Chrysis D, Takigawa M, Ritzen EM, Savendahl L. Locally produced estrogen promotes fetal rat metatarsal bone growth;: an effect mediated through increased chondrocyte proliferation and decreased apoptosis. JOURNAL OF ENDOCRINOLOGY 2006 188:2 193-203

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Fulltext: https://doi.org/10.1677/joe.1.06364
98 Laurencikas E, Savendahl L, Jorulf H. Metacarpophalangeal pattern profile analysis:: Useful diagnostic tool for differentiating between dyschondrosteosis, Turner syndrome, and hypochondroplasia. ACTA RADIOLOGICA 2006 47:5 518-24

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Fulltext: https://doi.org/10.1080/02841850600635939
99 Kalirai H, Phillip M, Savendahl L, Wit JM. The Fifth European Growth Plate Working Group Symposium - 21st September 2005, Lyon, France - Abstracts. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 2006 19:2 183-90

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Fulltext: https://doi.org/10.1515/jpem.2006.19.2.183
100 Chrysis D, Zaman F, Chagin AS, Takigawa M, Savendahl L. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3′-kinase signaling pathway. ENDOCRINOLOGY 2005 146:3 1391-7

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Fulltext: https://doi.org/10.1210/en.2004-1152
101 Kugelberg M, Shafiei K, Ohlsson C, Savendahl L, Zetterstrom C. Glucocorticoid eye drops inhibit growth in the newborn rabbit. ACTA PAEDIATRICA 2005 94:8 1096-101
102 Savendahl L. Hormonal regulation of growth plate cartilage. HORMONE RESEARCH 2005 64: 94-7

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Fulltext: https://doi.org/10.1159/000087764
103 Laurencikas E, Soderman E, Davenport M, Jorulf H, Savendahl L. Metacarpophalangeal pattern profile analysis as a tool for early diagnosis of Turner syndrome. ACTA RADIOLOGICA 2005 46:4 424-30

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Fulltext: https://doi.org/10.1080/02841850510020905
104 Kugelberg M, Ohlsson C, Savendahl L. Reduced bone mineral density and radial bone growth in young rabbits treated with dexamethasone eye drops. HORMONE RESEARCH 2005 63:4 165-70

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Fulltext: https://doi.org/10.1159/000084684
105 Tivesten A, Moverare-Skrtic S, Chagin A, Venken K, Salmon P, Vanderschueren D, Savendahl L, Holmang A, Ohlsson C. Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats. JOURNAL OF BONE AND MINERAL RESEARCH 2004 19:11 1833-9

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Fulltext: https://doi.org/10.1359/JBMR.040819
106 Chagin AS, Lindberg MK, Andersson N, Moverare S, Gustafsson JA, Savendahl L, Ohlsson C. Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice. JOURNAL OF BONE AND MINERAL RESEARCH 2004 19:1 72-7

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Fulltext: https://doi.org/10.1359/JBMR.0301203
107 Martensson K, Chrysis D, Savendahl L. Interleukin-1β and TNF-α act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones. JOURNAL OF BONE AND MINERAL RESEARCH 2004 19:11 1805-12

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Fulltext: https://doi.org/10.1359/JBMR.040805
108 Chrysis D, Ritzen EM, Savendahl L. Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes. JOURNAL OF ENDOCRINOLOGY 2003 176:3 331-7

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Fulltext: https://doi.org/10.1677/joe.0.1760331
109 Nilsson O, Chrysis D, Pajulo I, Boman A, Holst M, Rubinstein J, Ritzen EM, Savendahl L. Localization of estrogen receptors-α and -β and androgen receptor in the human growth plate at different pubertal stages. JOURNAL OF ENDOCRINOLOGY 2003 177:2 319-26

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Fulltext: https://doi.org/10.1677/joe.0.1770319
110 Nilsson O, Falk J, Ritzen EM, Baron J, Savendahl L. Raloxifene acts as an estrogen agonist on the rabbit growth plate. ENDOCRINOLOGY 2003 144:4 1481-5

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Fulltext: https://doi.org/10.1210/en.2002-221108
111 Chrysis D, Nilsson O, Ritzen EM, Savendahl L. Apoptosis is developmentally regulated in rat growth plate. ENDOCRINE 2002 18:3 271-8

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Fulltext: https://doi.org/10.1385/ENDO:18:3:271
112 Nilsson O, Abad V, Chrysis D, Ritzen EM, Savendahl L, Baron J. Estrogen receptor-α and -β are expressed throughout postnatal development in the rat and rabbit growth plate. JOURNAL OF ENDOCRINOLOGY 2002 173:3 407-14

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Fulltext: https://doi.org/10.1677/joe.0.1730407
113 Kindblom JM, Nilsson O, Hurme T, Ohlsson C, Savendahl L. Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. JOURNAL OF ENDOCRINOLOGY 2002 174:2 R1-6

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Fulltext: https://doi.org/10.1677/joe.0.174r001
114 Davenport ML, Punyasavatsut N, Stewart PW, Gunther DF, Savendahl L, Sybert VP. Growth failure in early life:: An important manifestation of Turner syndrome. HORMONE RESEARCH 2002 57:5-6 157-64

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Fulltext: https://doi.org/10.1159/000058376
115 Sjogren K, Hellberg N, Bohlooly-Y M, Savendahl L, Johansson MS, Berglindh T, Bosaeus I, Ohlsson C. Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry technique. JOURNAL OF NUTRITION 2001 131:11 2963-6

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Fulltext: https://doi.org/10.1093/jn/131.11.2963
116 Savendahl L, Davenport ML. Delayed diagnoses of Turner's syndrome:: Proposed guidelines for change. JOURNAL OF PEDIATRICS 2000 137:4 455-9

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Fulltext: https://doi.org/10.1067/mpd.2000.107390
117 Ritzen EM, Nilsson O, Grigelioniene G, Holst M, Savendahl L, Wroblewski J. Estrogens and human growth. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2000 74:5 383-6
118 Nilsson LO, Boman A, Savendahl L, Grigelioniene G, Ohlsson C, Ritzen EM, Wroblewski J. Demonstration of estrogen receptor-β immunoreactivity in human growth plate cartilage. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 1999 84:1 370-3

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Fulltext: https://doi.org/10.1210/jcem.84.1.5531
119 Vidal O, Lindberg M, Savendahl L, Lubahn DB, Ritzen EM, Gustafsson JA, Ohlsson C. Disproportional body growth in female estrogen receptor-α-inactivated mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1999 265:2 569-71

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Fulltext: https://doi.org/10.1006/bbrc.1999.1711
120 Savendahl L, Underwood LE. Fasting increases serum total cholesterol, LDL cholesterol and apolipoprotein B in healthy, nonobese humans. JOURNAL OF NUTRITION 1999 129:11 2005-8

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Fulltext: https://doi.org/10.1093/jn/129.11.2005
121 Davenport ML, Punyasavatsut N, Gunther D, Savendahl L, Stewart PW. Turner syndrome: a pattern of early growth failure. ACTA PAEDIATRICA 1999 88: 118-21
122 Savendahl L, Underwood LE. Decreased interleukin-2 production from cultured peripheral blood mononuclear cells in human acute starvation. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 1997 82:4 1177-80

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Fulltext: https://doi.org/10.1210/jcem.82.4.3865
123 Savendahl L, Underwood LE, Haldeman KM, Ulshen MH, Lund PK. Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. ENDOCRINOLOGY 1997 138:2 734-40

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Fulltext: https://doi.org/10.1210/endo.138.2.4941
124 Savendahl L, Mar MH, Underwood LE, Zeisel SH. Prolonged fasting in humans results in diminished plasma choline concentrations but does not cause liver dysfunction. AMERICAN JOURNAL OF CLINICAL NUTRITION 1997 66:3 622-5

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Fulltext: https://doi.org/10.1093/ajcn/66.3.622
125 Lindstrom P, Savendahl L. Enrichment of type I and type II rat somatotrophs: Characterization of growth hormone secretion in vitro. ENDOCRINOLOGY 1996 137:10 4174-80
126 ENGSTROM KG, SAVENDAHL L. CELL-VOLUME AND SHAPE OSCILLATIONS IN RAT TYPE-II SOMATOTROPHS AT HYPOTONIC CONDITIONS. CYTOMETRY 1995 20:1 7-13

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Fulltext: https://doi.org/10.1002/cyto.990200103
127 SAVENDAHL LSG, GRANKVIST K, ENGSTROM KG. GROWTH-HORMONE DEFICIENCY IMPAIRS BLOOD-CLOTTING AND REDUCES FACTOR-VII COAGULANT ACTIVITY IN RAT. THROMBOSIS AND HAEMOSTASIS 1995 73:4 626-9

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Review

1 Velentza L, Zaman F, Sävendahl L. Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia. Critical reviews in oncology/hematology 2021 168: 103492-
2 Wood CL, Soucek O, Wong SC, Zaman F, Farquharson C, Savendahl L, Ahmed SF. Animal models to explore the effects of glucocorticoids on skeletal growth and structure. The Journal of endocrinology 2018 236:1 R69-R91

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Fulltext: https://doi.org/10.1530/JOE-17-0361
3 Benyi E, Sävendahl L. The Physiology of Childhood Growth: Hormonal Regulation. Hormone research in paediatrics 2017 88:1 6-14

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Fulltext: https://doi.org/10.1159/000471876
4 Hokken-Koelega A, van der Lely AJ, Hauffa B, Häusler G, Johannsson G, Maghnie M, Argente J, DeSchepper J, Gleeson H, Gregory JW, Höybye C, Keleştimur F, Luger A, Müller HL, Neggers S, Popovic-Brkic V, Porcu E, Sävendahl L, Shalet S, Spiliotis B, Tauber M. Bridging the gap: metabolic and endocrine care of patients during transition. Endocrine connections 2016 5:6 R44-R54

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Fulltext: https://doi.org/10.1530/EC-16-0028
5 Baron J, Sävendahl L, De Luca F, Dauber A, Phillip M, Wit JM, Nilsson O. Short and tall stature: a new paradigm emerges. Nature reviews. Endocrinology 2015 11:12 735-46

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Fulltext: https://doi.org/10.1038/nrendo.2015.165
6 Sederquist B, Fernandez-Vojvodich P, Zaman F, Sävendahl L. Recent research on the growth plate: Impact of inflammatory cytokines on longitudinal bone growth. Journal of molecular endocrinology 2014 53:1 T35-44

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Fulltext: https://doi.org/10.1530/JME-14-0006
7 Karimian E, Sävendahl L. Estrogen signaling in growth plate cartilage. Endocrine development 2011 21: 42-51

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Fulltext: https://doi.org/10.1159/000328126
8 Cassorla F, Cianfarani S, Haverkamp F, Labarta JI, Loche S, Luo X, Maghnie M, Mericq V, Muzsnai A, Norgren S, Ojaniemi M, Pribilincova Z, Quinteiro S, Savendahl L, Spinola e Castro A, Gasteyger C. Growth hormone and treatment outcomes: expert review of current clinical practice. Pediatric endocrinology reviews : PER 2011 9:2 554-65

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9 Emons J, Chagin AS, Savendahl L, Karperien M, Wit JM. Mechanisms of Growth Plate Maturation and Epiphyseal Fusion. HORMONE RESEARCH IN PAEDIATRICS 2011 75:6 383-91

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Fulltext: https://doi.org/10.1159/000327788
10 Martin DD, Wit JM, Hochberg Z, Savendahl L, van Rijn RR, Fricke O, Cameron N, Caliebe J, Hertel T, Kiepe D, Albertsson-Wikland K, Thodberg HH, Binder G, Ranke MB. The Use of Bone Age in Clinical Practice - Part 1. HORMONE RESEARCH IN PAEDIATRICS 2011 76:1 1-9

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Fulltext: https://doi.org/10.1159/000329372
11 Andrade AC, Baron J, Manolagas SC, Shaw NJ, Rappold GA, Donaldson MDC, Gault EJ, Savendahl L. Hormones and Genes of Importance in Bone Physiology and Their Influence on Bone Mineralization and Growth in Turner Syndrome. HORMONE RESEARCH IN PAEDIATRICS 2010 73:3 161-5

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Fulltext: https://doi.org/10.1159/000284356
12 Benjamin RW, Moats-Staats BM, Calikoglu's A, Savendahl L, Chrysis D. Hypercalcemia in children. Pediatric endocrinology reviews : PER 2008 5:3 778-84

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13 Chagin AS, Sävendahl L. Estrogens and growth: review. Pediatric endocrinology reviews : PER 2007 4:4 329-34

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14 Chagin AS, Savendahl L. Oestrogen receptors and linear bone growth. ACTA PAEDIATRICA 2007 96:9 1275-9

Letter

1 Sävendahl L, Battelino T, Brod M, Højby Rasmussen M, Juul Kildemoes R, Saenger P. Letter to the Editor From Sävendahl et al.: "Weekly Lonapegsomatropin in Treatment-Naïve Children With Growth Hormone Deficiency: The Phase 3 heiGHt Trial". The Journal of clinical endocrinology and metabolism 2022 107:2 e888-e889

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Fulltext: https://doi.org/10.1210/clinem/dgab736
2 Tidblad A, Sävendahl L. Growth Hormone Use in Childhood and Adult Cardiovascular Disease-Reply. JAMA pediatrics 2021 175:6 646-647
3 Zaman F, Savendahl L. New Agents to Treat Chronic Lymphocytic Leukemia. The New England journal of medicine 2016 374:22 2185-

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Fulltext: https://doi.org/10.1056/NEJMc1602674
4 Zaman F, Kogner P, Savendahl L. Venetoclax in cancer therapy and potential effects on bone. LANCET ONCOLOGY 2016 17:8 e319-e320
5 Eriksson E, Sävendahl L, Zaman F. Bortezomib and bone health in adults: can we extend these findings to children?. European journal of haematology 2013 90:6 533-4

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Fulltext: https://doi.org/10.1111/ejh.12101
6 Zaman F, Fadeel B, Savendahl L. Proteasome inhibition therapies in childhood cancer. LEUKEMIA 2008 22:4 883-4

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Fulltext: https://doi.org/10.1038/sj.leu.2404997
7 Davenport ML, Savendahl L. Screening for Turner's syndrome by chromosome analysis of all girls with short stature -: Reply. JOURNAL OF PEDIATRICS 2002 140:1 140-141

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Editorial

1 Fernandez-Vojvodich P, Zaman F, Sävendahl L. Interleukin-6 acts locally on the growth plate to impair bone growth. Annals of the rheumatic diseases 2013 72:10 e24-
2 Savendahl L. Vitamin D deficiency during pregnancy-potential threat to the child. ACTA PAEDIATRICA 2011 100:4 484-5

Other

1 Robertsson C, Sävendahl L, Cardemil C. Primary chronic osteomyelitis of the jaw: Rapid improvement after hormonal suppression in a girl with precocious puberty. Bone reports 2021 14: 101089-
2 Savendahl L, Battelino T, Brod M, Rasmussen MH, Horikawa R, Juul RV, Saenger P, REAL 3 Study Grp. Once-Weekly Somapacitan vs Daily GH in Children With GH Deficiency: Results From a Randomized Phase 2 Trial (vol 105, pg e1847, 2020). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2020 105:12

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Fulltext: https://doi.org/10.1210/clinem/dgaa614
3 Savendahl L, Polak M, Backeljauw P, Blair J, Miller B, Rohrer T, Pietropoli A, Ostrow V, Ross J. Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet® IOS and ANSWER Program (vol 104, pg 4730, 2019). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2020 105:6

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Fulltext: https://doi.org/10.1210/clinem/dgaa139
4 Sävendahl L, Pournara E, Pedersen BT, Blankenstein O. Is safety of childhood growth hormone therapy related to dose? Data from a large observational study. European journal of endocrinology 2017 176:3 X1-

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Fulltext: https://doi.org/10.1530/EJE-15-1017e
5 Lindahl E, Nyman U, Zaman F, Palmberg C, Cascante A, Shafqat J, Takigawa M, Sävendahl L, Jörnvall H, Joseph B. Proinsulin C-peptide regulates ribosomal RNA expression. The Journal of biological chemistry 2017 292:10 4382-

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Fulltext: https://doi.org/10.1074/jbc.A109.053587
6 Späth SS, Sävendahl L, Camacho-Hübner C, Nilsson O. Highlights from the Second European Workshop on Growth Plate Research 2010. Pediatric endocrinology reviews : PER 2010 8:2 123-5

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7 Ross J, Savendahl L, Gruters A, Oliver I, Peterkova V, Snajderova M, Germak J, Pedersen BT, Rakov V. Gender differences in growth hormone (GH) responsiveness in growth hormone deficient (GHD) children and short children born small for gestational age (SGA). HORMONE RESEARCH 2009 72: 372-372

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8 Savendahl L, Ross J, Fujieda K, Tajima T, Gruters A, Blankenstein O, Oliver I, Pienkowski C, Snajderova M, Peterkova V, Pedersen BT, Germak J, Rakov V. Gender disproportion in children treated with growth hormone depends on country/region, diagnosis and severity of growth retardation. HORMONE RESEARCH 2009 72: 373-373

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9 Emons JAM, Leijten J, van Zwet E, Goeman J, Decker E, Chagin A, Sticht C, Yu XL, van Gool SA, Pirzer H, Rappold GA, Gretz N, Wit JM, Savendahl L, Karperien M. Genome wide screening and morphological analysis of the human growth plate during pubertal development. HORMONE RESEARCH 2009 72: 275-276

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10 Heino TJ, Astrom E, Savendahl L, Soderhall S. Improved growth during the first year of monthly intravenous pamidronate therapy in prepubertal patients with osteogenesis imperfecta. HORMONE RESEARCH 2009 72: 223-223

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11 Ross J, Savendahl L, Karwe V, Rakov V, Germak J. Predictors of growth response after one year of Norditropin treatment in growth hormone deficient (GHD) patients from the ANSWER program® and NordiNet®. HORMONE RESEARCH 2009 72: 372-372

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12 Ross J, Savendahl L, Karwe V, Germak J, Rakov V. Predictors of growth response after one year of Norditropin® treatment in Turner syndrome patients from the ANSWER program® and the NordiNet®. HORMONE RESEARCH 2009 72: 372-373

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13 Karimian E, Savendahl L. Resveratrol modulates longitudinal bone growth of cultured fetal rat metatarsal bones in a biphasic manner. HORMONE RESEARCH 2009 72: 277-278

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14 Eriksson E, Johnsen JI, Kogner P, Savendahl L. The proteasome inhibitor, bortezomib induces growth retardation and delays tumor growth in young mice. HORMONE RESEARCH 2009 72: 276-276

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15 Zaman F, Chrysis D, Huntjens K, Takigawa M, Fadeel B, Savendahl L. Dexamethasone Triggers Mitochondrial Apoptosis Through Bax in Proliferative Growth Plate Chondrocytes Causing Growth Retardation. JOURNAL OF BONE AND MINERAL RESEARCH 2008 23: S53-S53

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16 Berner M, Wehtje H, Savendahl L. Efficacy and safety of bilateral epiphysiodesis performed in extremely tall girls and boys. HORMONE RESEARCH 2008 70: 113-113

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17 Emons J, Chagin AS, Hultenby K, Zhivotovsky B, Wit JM, Karperien M, Savendahl L. Epiphyseal fusion in the human growth plate does not involve classical apoptosis. HORMONE RESEARCH 2008 70: 37-37

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18 Heino TJ, Chagin AS, Savendahl L. GPR30 estrogen receptor expression in bone cells during pubertal development. CALCIFIED TISSUE INTERNATIONAL 2008 82: S155-S155

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19 Karperien M, Emons J, van Gool S, Chagin A, Savendahl L, Rappold G, Wit JM. Molecular regulation of the growth plate: Genome-wide expression analysis of human growth plate chondrocytes. An ESPE-RU update. HORMONE RESEARCH 2008 70: 9-9

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20 Eriksson E, Zaman F, Ysis DC, Savendahl L. Proteasome inhibition causes permanent growth retardation in young mice. HORMONE RESEARCH 2008 70: 37-38

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21 Windahl SH, Andersson N, Chagin A, Martensson UE, Carlsten H, Olde B, Leeb-Lundberg LMF, Swanson C, Savendahl L, Lagerquist MK, Ohlsson C. The Role of the G Protein-coupled Receptor GPR30 in Effects of Estrogen in Ovariectomized Mice.. JOURNAL OF BONE AND MINERAL RESEARCH 2008 23: S284-S284

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22 Sundstrom K, Chagin AS, Camacho-Hubner C, Savendahl L. Time-dependent growth responsiveness to rhIGF-I in cultured rat metatarsal bones. HORMONE RESEARCH 2008 70: 19-19

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23 Thodberg HH, Savendahl L. Validation of authomated bone age determination in healthy American children of four ethnicities. HORMONE RESEARCH 2008 70: 88-88

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24 Heino TJ, Chagin AS, Savendahl L. Bisphosphonates stimulate linear growth of fetal rat metatarsal bones and protect chondrocytes from dexamethasone-induced apoptosis. CALCIFIED TISSUE INTERNATIONAL 2007 80: S130-S130

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25 Miclea RL, Phillip M, Sävendahl L, Wit JM. Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, Finland. Pediatric endocrinology reviews : PER 2007 5:2 680-5

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26 Thodberg HH, Savendahl L. Accuracy of a new automatic method to determine Greulich-Pyle bone age. HORMONE RESEARCH 2006 65: 21-21

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27 Karimian E, Vojvodich PF, Savendahl L. Biologic response modifiers completely rescue cytokine-induced growth retardation in fetal rat metatarsal bones. HORMONE RESEARCH 2006 65: 28-28

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28 Savendahl L. Cytokines and their effect on growth plate chondrocytes. HORMONE RESEARCH 2006 65: 7-8

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29 Malmlof T, Chagin A, Tivesten A, Savendahl L. Estrogen induced VEGF-expression in the rat growth plate. HORMONE RESEARCH 2006 65: 27-28

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30 Eriksson E, Zaman F, Chrysis D, Savendahl L. Proteasome inhibitors induce growth retardation in mice and apoptosis in growth plate chondrocytes. HORMONE RESEARCH 2006 65: 20-20

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31 Chagin A, Nilsson M, Wright KD, Savendahl L. Remaining estrogenic activity in the man with mutated estrogen receptor alpha [ERα). HORMONE RESEARCH 2006 65: 28-28

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32 Emons J, Phillip M, Wit JM, Sävendahl L. The Sixth ESPE Growth Plate Working Group Symposium (EUROGROP), June 30th, Rotterdam, the Netherlands, "a multidisciplinary approach to growth plate biology". Pediatric endocrinology reviews : PER 2006 4:2 153-9

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33 Chagin A, Phillip M, Wit JM, Sävendahl L. The 4th European Growth Plate Working Group Symposium (EUROGROP). 10th September 2004, Basel, Switzerland. Journal of pediatric endocrinology & metabolism : JPEM 2005 18:8 823-7

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34 Moverare S, Tivesten A, Chagin A, Venken K, Salmon P, Vanderschueren D, Savendahl L, Holmang A, Ohlsson C. Additive stimulatory effects of estrogen and androgen receptor activation on trabecular bone in ovariectomized rats.. JOURNAL OF BONE AND MINERAL RESEARCH 2004 19: S170-S170

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35 Robson H, Savendahl L, Phillip M, Wit JM. The Third European Growth Plate Working Group Symposium. 17th September 2003, Ljubljana, Slovenia. Journal of pediatric endocrinology & metabolism : JPEM 2004 17:4 685-94
36 Nilsson O, Falk J, Ritzen ME, Baron J, Savendahl L. Raloxifene acts as an estrogen agonist on the rabbit growth plate. PEDIATRIC RESEARCH 2003 53:4 151A-152A

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37 Nilsson O, Abad V, Savendahl LSG, Baron J. Expression of estrogen receptor-β in rabbit growth plate cartilage.. JOURNAL OF BONE AND MINERAL RESEARCH 1999 14: S452-S452

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